- Core Center：Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University
- Principal Investigator：Chie Naruse
- FAX：+81-75-753-4409
- Sub-Core Center 1：The Institute of Medical Sciences, The University of Tokyo
- Sub-Core Center 2 (Backup)：Experimental Animal Division, RIKEN BioResource Research Center
概要Overview
Rats exhibit behaviors and metabolic systems thatresemble those of humans, and their moderate size facilitates experimental procedures. Rats are also amenable to strict control of genetic and environmental factors. Because of these superior properties, various rat disease models have been developed and used in medicine, pharmacology, life science, nutrition, neuroscience, genetics and other fields. Recent developments in genome editing technology have enabled the development of complex genetically modified rats, further increasing their value as a bioresource.
Stock
・Number of strains available: about 800 strains
・Information on 109 physiological characteristics: about 200 strains
・Genomic DNA and frozen sperm from ENU mutagenesis: about 10,000 rats
・Recombinant inbred lines between LE/Stm and F344/Stm: 34 lines
・Genome sequencing information on F344/Stm lines and more.
Subjects in the NBRP programs related to “Rats”
【 Value addition subprogram／Genome Information Upgrading Program】
| FY2016 | Whole genome resequencing of the representative rat strains and development of a SNP typing kit |
| FY2015 | Targeted genome resequencing of 20 strains of the rats |
| FY2011 | Whole genome sequencing of F344 rat |
| FY2008 | Rat LE/Stm BAC end sequencing |
| FY2005-FY2006 | Genome Information Upgrading Program : FY2002-FY2006 |
【 Technology development subprogram／Fundamental Technology Upgrading Program】
| FY2023-FY2024 | Creドライバーラットの網羅的/局所的/機能的な解析技術の開発 (in Japanese) |
| FY2019-FY2020 | Development of reproductive engineering in rats; the effective operation and the expansion of new users (in Japanese) |
| FY2016 | Development of easy protocols for efficient gene knock-in using genome editing technology (in Japanese) |
| FY2010-FY2011 | Improving the efficiency of sperm preservation technologies in rats |
| FY2007-FY2008 | Development of transportation systems for mouse and rat resources |