- Core Facility：Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University
- Principal Investigator：Masahide Asano
- Sub-Core Facility 1：The Institute of Medical Sciences, The University of Tokyo
- Sub-Core Facility 2 (Backup)：Experimental Animal Division, RIKEN BioResource Research Center
The rat is the mammal which is used in many fields of research owing to its suitable size, adaptability and neurological characteristics. Recent developments including the establishment of rat ES/iPS cells and the generation of gene knockout rats using gene editing nucleases (ZFN/TALEN/Cas9) technology etc. will boost the utility of the rat as biological resource.
The Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, conducts a rat strain-based collection, preservation and distribution program and quality assurance through microbial and genetic monitoring, enhances rat strain databases and holds the Rat Resource Research Meeting to support and stimulate science in the rat research community. Riken BRC, backs up frozen embryos and sperm, and the University of Tokyo, preserves and supplies immunodeficient rats, respectively, to support the central facility at Kyoto University as a sub center.
The NBRP-Rat has been developed with the intent of being the world’s leading rat resource center. This project promotes further utilization of the rat as a research tool in many fields of science.
So far, approximately 900 different strains have been deposited to NBRP-Rat. The repository includes spontaneous mutants, recombinant inbred, congenic, consomic, transgenic, and knock out rats. These strains are utilized in fields as neurobiology, cardiovascular disease/hypertension, diabetes/obesity, cancer, immunology, development and metabolism.
Subjects in the NBRP programs “Genome information upgrading program” and “Fundamental technology upgrading program” related to “Rats”
【 Genome information upgrading program 】
|FY2016||Whole genome resequencing of the representative rat strains and development of a SNP typing kit|
|FY2015||Targeted genome resequencing of 20 strains of the rats|
|FY2011||Whole genome sequencing of F344 rat|
|FY2008||Rat LE/Stm BAC end sequencing|
|FY2005-FY2006||Genome Information Upgrading Program : FY2002-FY2006|