- Core Center：RIKEN Center for Brain Science
- Principal Investigator：Hitoshi Okamoto
- Sub-Core Center 1：Genetic Resource Center, National Institute of Genetics
- Sub-Core Center 2：Exploratory Research Center on Life and Living Systems, National Institutes of Natural Sciences
概要Overview
Zebrafish are vertebrates that remain transparent throughout embryogenesis. They are also easy to breed, have a short life cycle, and are amenable to mutation and genetic modification. As a result of these characteristics, zebrafish are used to study biological regulatory processes such as those involved in development and regeneration using molecular genetics and imaging technology. Use of zebrafish as a substitute for mammalian models has increased in recent years, reflecting the rise in awareness of animal welfare issues.
Stock
・Wild-type: 1 strain
・Mutant lines: about 400 strains
・Transgenic lines: about 1,800 strains
・TILLING: 4,000 strains
Subjects in the NBRP programs “Genome information upgrading program” and “Fundamental technology upgrading program” related to “Zebrafish”
【 Genome information upgrading program 】
| FY2018 | Genetic analysis of zebrafish transgenic and inbred lines (in Japanese) |
【 Fundamental technology upgrading program 】
| FY2019-FY2020 | Development of transgenic fish lines that label and manipulate specific cell types (in Japanese) |
| FY2016 | Development of easy protocols for efficient gene knock-in using genome editing technology (in Japanese) |