Mice are used as model animals for human widely in the life science research and development. To meet social and research needs, the Experimental Animal Division of the RIKEN BioResource Research Center (BRC) has operated to collect, preserve, quality quality-control and distribute mouse models created in Japan for the study of higher biological functions and conquering diseases. Our mice are cleaned cleaned-up to specific pathogen pathogen-free state, strictly monitored for their health and genetic modifications. Genomic, gene expression and phenotypic information are added to enrich their value to establish mouse resources of the world highest standard. As an international hub, RIKEN BRC participates in the International Mouse Strain Resource, IMSR and registers strains created by Japanese scientists and disseminate the mice around the world. We have also promoted Asian/Australian networks to strengthen regional cooperation and participated with other BRC groups in the International Mouse Phenotyping Consortium (IMPC) to contribute to basic medical sciences and drug discovery by producing knockout mice for every coding gene, generating broad broad-based phenotypic data, and making them available to scientists around the world (Nature 537:508 508-514, 2017).
We have approximately 9,000 mouse strains as follows: inbred mice, spontaneous and induced mutants, Cre and FLP driver strains and transgenic mice to visualize various phenomena, mice with targeted mutations such as knock knock-out and knock knock-in, congenic strains, strains with chromosomal abnormalities and chromosomal recombination, and wild wild-derived mouse strains.
Subjects in the NBRP programs “Genome information upgrading program” and “Fundamental technology upgrading program” related to “Mice”
【 Genome information upgrading program 】
|FY2020||Long-read sequencing of disease model mouse strains established in Japan|
|FY2017||Genome resequencing of Japanese fancy mouse-derived JF1/Ms strain (in Japanese)|
|FY2016||Genome resequencing of Japanese wild mouse-derived MSM/Ms strain|
|FY2015||Sequence and structure determination and open to public of reference mouse genome based on long one-molecule sequencing|
|FY2010||Completion of BAC end sequencing of the mouse C57BL/6N substrain|
|FY2009||BAC end sequencing of the mouse C57BL/6N substrain|
|FY2002-FY2006||Genome Information Upgrading Program : FY2002-FY2006|