- Core Center：Experimental Animal Division, RIKEN BioResource Research Center
- Principal Investigator：Atsushi Yoshiki
- FAX：+81-29-836-9010
概要Overview
Mice are widely used as animal models in life science research to understand higher order biological phenomena, identify approaches to promote human health and conquer diseases. Numerous geneticallyuniform inbred mouse strains and their genomic information are available for research purposes. Additionally, gene-modified mice are being actively generated using gene-targeting in embryonic stem cells and genome-editing in fertilized eggs using CRISPR/Cas9 technology.
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The RIKEN BioResource Research Center (BRC) has about 9,500 mouse strains predominantly gene-modified strains (e.g., Tg, KO, cKO, KI mice), including:
・Human disease models：about 220 strains
・Cre/Flp driver mice：about 230 strains
・Fluorescent and luminescent reporter mice：about 1,000 strains
Subjects in the NBRP programs “Genome information upgrading program” and “Fundamental technology upgrading program” related to “Mice”
【 Genome information upgrading program 】
| FY2020 | Long-read sequencing of disease model mouse strains established in Japan |
| FY2017 | Genome resequencing of Japanese fancy mouse-derived JF1/Ms strain (in Japanese) |
| FY2016 | Genome resequencing of Japanese wild mouse-derived MSM/Ms strain |
| FY2015 | Sequence and structure determination and open to public of reference mouse genome based on long one-molecule sequencing |
| FY2010 | Completion of BAC end sequencing of the mouse C57BL/6N substrain |
| FY2009 | BAC end sequencing of the mouse C57BL/6N substrain |
| FY2002-FY2006 | Genome Information Upgrading Program : FY2002-FY2006 |