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NBRP Genome Information Upgrading Program Project's Progress

Mice

Focus Genome resequencing of Japanese wild mouse-derived MSM/Ms strain
Principal Investigator Toyoyuki Takada  National Institute of Genetics
Project Period FY2016
Overview   The laboratory mouse is one of the most important bioresources for studying principles underlying higher-order biological phenomena and etiologies of human diseases. National Institute of Genetics (NIG) has established a series of mouse experimental strains named “Mishima Battery” since 1970’s. It consists of ten inbred strains originated from three or four subspecies of Mus musculus, which are widely distributed in the world. These strains have very remote genetic status from the commonly used laboratory mouse strains such as C57BL/6J (B6), and show very unique phenotypes. The mouse strains in “Mishima Battery” are now distributed to the science research community via RIKEN BioResource center, and contribute to broad range of life science. NIG also established B6-ChrNMSM consomic strains, in which every chromosome of B6 is substituted by corresponding chromosome of Japanese wild mouse-derived MSM/Ms (MSM) strain, which is a member of “Mishima Battery”.
  For genome analysis of MSM, we previously performed a resequencing project of MSM, which was supported by “NBRP genome information upgrading program” and KAKENHI on Priority Areas “Comparative Genomics”. Our study revealed more than ten millions of nucleotide substitutions between B6 reference genome and the MSM genome. In this program, to elucidate more in detail of structure and copy number variation, further resequencing by single molecule and real-time sequencing system is employed for the MSM genome as collaboration with Comparative Genomics Laboratory, and Advanced Genomics Center, NIG, and Joint Support-Center for Data Science Research, ROIS. Upcoming resequenced data will be open to public to increase usability of the MSM genome information for the research community via NIG mouse genome database “NIG_MoG” (http://molossinus.nig.ac.jp/msmdb/index.jsp).
Project's Progress